You should not use this medicine if you have had an allergic reaction to drotrecogin alfa, or if you have recently had a stroke, severe head or spine injury, head trauma, brain tumor, or any type of severe bleeding. You should not use this medicine if you have a catheter in your back for pain medicine or anesthetics (sometimes called "epidural").
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are using abciximab (Reopro®), eptifibatide (Integrilin®), tirofiban (Aggrastat®), a blood thinner (such as warfarin or Coumadin®), aspirin, streptokinase (Streptase®), or other medicine that affects blood platelets (such as dextran, dipyridamole, hydroxychloroquine, ibuprofen, indomethacin, phenylbutazone, Advil®, Aggrenox®, InfeD®, Indocin®, Motrin®, Persantine®, or Plaquenil®).
Make sure your doctor knows if you are pregnant or breastfeeding, or if you have a bleeding disorder, liver disease, or a history of blood clots, stroke, aneurysm, or bleeding in your stomach.
You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off. Stay away from situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
Watch for any bleeding from open areas such as around the injection site. Also check for blood in your urine or stool. If you have any bleeding or injuries, tell your doctor right away.