You should not use estropipate if you are pregnant (or may become pregnant) or breastfeeding. You should not use this medicine if you have ever had an allergic reaction to any estrogens. Before using estropipate, tell your doctor if you have known or suspected breast cancer, unusual vaginal bleeding, or a history of blood clots.
Check with your doctor before taking estropipate if you have high blood pressure, diabetes, seizure disorders (epilepsy), high blood calcium or triglyceride levels, breast lumps, migraine headaches, heart disorders, or liver or kidney problems.
Regular visits to your doctor (usually every 6 months to 1 year) are needed while taking this medicine.
Large doses of this medicine taken over long periods of time may increase the risk of some kinds of cancer. Talk to your doctor about this risk.
Unless you have had a hysterectomy (uterus removed), check with your doctor about whether you should also take progesterone.