You should not receive this medicine if you have had an allergic reaction to ixabepilone or Cremophor® EL (polyoxyethylated castor oil). Do not take this medicine if you are pregnant, or if you have neutropenia (low white blood cell count), thrombocytopenia (low platelet count), or severe liver disease.
Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins.
You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
You will be given other medicines before you are given ixabepilone. These medicines may help prevent some of the side effects of ixabepilone.
If a dose is missed:
This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are using certain antibiotics (such as clarithromycin, erythromycin, rifabutin, rifampicin, rifampin, telithromycin, Biaxin®, Ilosone®, Ketek®, Mycobutin®, Rifadin®, or Rimactane®), medicine to treat fungal infections (such as fluconazole, itraconazole, ketoconazole, voriconazole, Diflucan®, Nizoral®, Sporanox®, or Vfend®), or medicine to treat HIV or AIDS (such as amprenavir, atazanavir, delavirdine, indinavir, nelfinavir, ritonavir, saquinavir, Agenerase®, Crixivan®, Fortovase®, Invirase®, Norvir®, Rescriptor®, Reyataz®, or Viracept®).
Tell your doctor if you are also using medicine for seizures (such as carbamazepine, phenobarbital, phenytoin, Dilantin®, or Tegretol®), verapamil (Verelan®), dexamethasone (Decadron®), nefazodone (Serzone®), or St. John's wort.
Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
Make sure your doctor knows if you are breastfeeding, or if you have liver disease, diabetes, nerve problems (such as tingling or numbness), or a history of heart disease.
This medicine lowers the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers.
This medicine may cause a serious allergic reaction that can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble with breathing, chest pain, or swelling of the face, tongue, and throat after you get the injection.
Cancer medicines can cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
This medicine contains alcohol which may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.