Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are using other medicines to dissolve blood clots (such as streptokinase or Streptase®), a blood thinner (such as warfarin or Coumadin®), or pain or arthritis medicine (such as aspirin, ibuprofen, naproxen, Advil®, Aleve®, Ecotrin®, or Motrin®).
Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have kidney disease, liver disease, blood vessel disorders, or if you have recently had surgery or dental work.
Some medical conditions may make using lepirudin dangerous because it increases your risk of bleeding. These conditions include any type of bleeding in your body (such as a bleeding ulcer), or a bleeding disorder such as hemophilia. Other conditions include uncontrolled high blood pressure, a bacterial infection of the heart, or a history of strokes.
You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off. Stay away from situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Avoid picking your nose. If you need to blow your nose, blow it gently.
Watch for any bleeding from open areas such as around your injection site. Also check for blood in your urine or stools. Tell your doctor right away if you have any bleeding or injuries.
This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble breathing; or chest pain after you get the injection.
Serious side effects can occur even up to several weeks after you have stopped receiving this medicine. Check with your doctor right away if you have any unusual side effects while you are using this medicine or after you stop using this medicine.
Your doctor will need to check your blood at regular visits while you are using this medicine. Be sure to keep all appointments.