Given to prevent the harmful effects of methotrexate (a cancer medicine) in patients with bone cancer (osteosarcoma). Also given to patients who receive too much methotrexate for other conditions. This medicine acts in the body like folic acid (vitamin B9).
You should not use this medicine if you have had an allergic reaction to levoleucovorin or similar medicines such as folic acid (Folvite®) and folinic acid. This medicine should not be used if you have certain blood problems such as anemia caused by a lack of vitamin B12.
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are using 5-fluorouracil (Adrucil®) or a combination of trimethoprim and sulfamethoxazole (Bactrim® or Septra®). Tell your doctor if you are also using medicine to treat seizures (such as phenobarbital, phenytoin, primidone, Luminal®, Dilantin®, or Mysoline®).