You should not use this medicine if you have had an allergic reaction to loperamide or simethicone. Do not use this medicine if you have a fever, if you have blood in your stools, or if you are bleeding from your rectum.
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
Make sure your doctor knows if you are also using any type of antibiotic. Diarrhea is a side effect of many antibiotics. In most cases, you should not take medicine to stop diarrhea that is caused by certain antibiotics. Talk with your doctor if you think your diarrhea may be caused by your recent use of an antibiotic medicine.