You should not use this medicine if you have ever had an allergic reaction to perphenazine, Compazine®, Mellaril®, amitriptyline (Elavil®), or other antidepressants. This medicine should not be taken with monoamine oxidase (MAO) inhibitors (Marplan®, Nardil®, Parnate®).
Your doctor will tell you how much medicine to take and how often.
You may take your tablets with food to avoid stomach upset.
This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. Your doctor might ask you to sign some forms to show that you understand this information.
If a dose is missed:
Take the missed dose as soon as possible.
If it is almost time (within 2 hours) for the next dose, skip the missed dose and return to your regular dosing schedule.
If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
Talk to your doctor before taking this medicine if you have heart disease, liver disease, epilepsy, glaucoma, or any other medical problem.
For some children and teenagers, this medicine can increase thoughts of suicide. All of the warnings in this leaflet are true for a child or teenager who is using this medicine. Tell your doctor right away if you start to feel more depressed. Also tell your doctor right away if you have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure your caregiver knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell your doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let your doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.
While taking this medicine, avoid becoming overheated during exercise and hot weather. This can result in heat stroke. Do not stay out in the sun too long.
This medicine may cause drowsiness. Be careful when driving a car or operating heavy machines.
There is a risk of side effects that include muscle spasms, twitching in the face and body, and uncontrolled tongue or jaw movement. Talk to your doctor about this risk.
If you have been taking this medicine for a long time or in large doses, ask your doctor before you stop taking the medicine. You may need to take less and less before stopping completely.