You should not use this medicine if you have had an allergic reaction to phenelzine. Do not use this medicine if you have high blood pressure, liver disease, heart disease, or severe kidney disease. Do not use this medicine if you have severe or frequent headaches, or pheochromocytoma (a tumor of the adrenal gland). You should not use this medicine if you have ever had a stroke, transient ischemic attack (TIA), or any other kind of cerebrovascular disease. There are many medicines that you should not use while you are using phenelzine. This includes medicine you can buy without a prescription (over-the counter). Make sure your doctor knows about all other medicines you are using. If you were using another MAO inhibitor (such as isocarboxazid, selegiline, tranylcypromine, Eldepryl®, Emsam®, Marplan®, or Parnate®) for your depression, you must wait at least 14 days before you can start using phenelzine. If you were using fluoxetine (Prozac®) for your depression, you must wait at least 5 weeks before you can start using phenelzine. If you stop using phenelzine, you must wait at least 14 days before starting another medicine for your depression. Some medicines for depression include amitriptyline, amoxapine, buspirone, carbamazepine, clomipramine, cyclobenzaprine, desipramine, doxepin, fluoxetine, imipramine, maprotiline, mirtazapine, nortriptyline, perphenazine, protriptyline, trimipramine, Anafranil®, Asendin®, Aventyl®, Buspar®, Carbatrol®, Elavil®, Flexeril®, Ludiomil®, Norpramin®, Pamelor®, Prozac®, Remeron®, Sinequan®, Surmontil®, Tegretol®, Tofranil®, Trilafon®, or Vivactil®. You should not use this medicine if you are also using an amphetamine (Desoxyn®, Dexedrine®), cocaine, epinephrine (Adrenalin Chloride®, Sus-Phrine®), levodopa (Dopar®, Larodopa®), methyldopa (Aldomet®), methylphenidate (Methylin®, Ritalin®), phenylalanine, tryptophan, or tyrosine. Do not use this medicine if you are using bupropion (Wellbutrin®), dextromethorphan (Benylin®), or meperidine (Demerol®). You should not use this medicine if you are also using citalopram (Celexa®), fluvoxamine (Luvox®), guanethidine (Ismelin®), paroxetine (Paxil®), sertraline (Zoloft®), or venlafaxine (Effexor®).