You should not use this medicine if you have had an allergic reaction to primaquine or if you have severe rheumatoid arthritis or lupus. You should not use this medicine if you are also taking quinacrine or medicines that affect your bone marrow such as some anti-cancer drugs.
If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
Talk to your doctor before taking this medicine if you have a G-6-PD (glucose-6-phosphate dehydrogenase) deficiency or if you or any close relative has a type of anemia (a blood disorder) called hemolytic anemia or favism.
This medicine may cause harmful side effects such as certain kinds of anemia and other blood problems. Your doctor may need to test your blood regularly while you are taking this medicine. Try to keep all of the appointments your doctor makes for you.