You should not use this medicine if you have ever had an allergic reaction to tolbutamide or other sulfonylurea drugs such as Tolinase®, chlorpropamide, or Glucotrol®. You should not use this medicine if you are pregnant.
Talk with your doctor before taking this medicine if you are breastfeeding or if you have liver, kidney, or heart disease, G-6-PD deficiency, or a thyroid disorder.
To control your diabetes, follow the diet that your doctor orders and take this medicine on a regular schedule.
You may have low blood sugar while you are taking tolbutamide, especially if you miss a meal, exercise for a long time, or drink alcohol. Symptoms of low blood sugar include sweating, feeling very hungry, fast heartbeat, drowsiness, confusion, headache that won't go away, chills, or vomiting.
Ask your doctor what you should do in case you have low blood sugar. You will need to control it quickly.
Make sure your doctor knows you are taking this medicine before you have any kind of surgery.
This medicine may make your skin sensitive to sunlight. Use a sunscreen when outdoors. Avoid sunlamps or tanning beds.