Most cases of histoplasmosis clear up without specific treatment. Patients are advised to rest and take medication to control fever.
If you are sick for more than 1 month or are having breathing problems, your doctor may prescribe medication. Drugs used to treat this condition include itraconazole and amphotericin B.
When histoplasmosis infection is severe or gets worse, the illness may last for 1 to 6 months. Even then, it is rarely fatal.
It can be a serious illness in people with weak immune systems, such as those who:
Acute pulmonary histoplasmosis can get worse over time, or can become chronic pulmonary histoplasmosis (which doesn't go away).
Histoplasmosis can spread to other organs through the bloodstream (dissemination). This is usually seen in infants, young children, and patients with a suppressed immune system.
Call your health care provider if:
Kauffman CA. Histoplasmosis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, PA: Saunders Elsevier; 2007:chap 353.
Waht LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45(7):807-825.
© 2011 University of Maryland Medical Center (UMMC). All rights reserved.
UMMC is a member of the University of Maryland Medical System,
22 S. Greene Street, Baltimore, MD 21201. TDD: 1-800-735-2258 or 1.866.408.6885