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Drug-induced cholestasis

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Definition:

Drug-induced cholestasis is the blockage of the flow of bile from the liver caused by medication.

Alternative Names:

Cholestasis - drug-induced

Causes, incidence, and risk factors:

Bile is produced in the liver, moved to the gallbladder and excreted into the gut through the biliary tract , to aid in the digestion of fats. Flow from the liver to the gallbladder and ultimately to the gut can be slowed or stopped by certain drugs. When the flow of bile is inhibited, an individual may become jaundiced (yellow coloration to the eyes and skin). Drugs which cause cholestasis (absence of flow of bile) may damage the liver.

Many drugs can cause cholestasis. Some more common culprits include: gold salts, nitrofurantoin, anabolic steroids, oral contraceptives, chlorpromazine, prochlorperazine, sulindac, cimetidine, erythromycin, tobutamide, imipramine, ampicillin and other penicillin-based antibiotics. This list is not comprehensive, as other medications can also unexpectedly cause cholestasis in some individuals.

• Review Date: 7/25/2006
• Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-TorresdaleHospital, Jefferson Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

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