Definition of Gilbert's disease:

Gilbert's disease is a common disorder passed down through families. It affects the way bilirubin is processed by the liver, and causes jaundice.

Causes, incidence, and risk factors:

Gilbert's disease affects up to 10% of people in some Caucasian populations.

Symptoms:

• Fatigue
• Yellowing of the skin and whites of the eyes (mild jaundice)

Note: In people with Gilbert's syndrome, jaundice typically appears during times of exertion, stress, and infection, or when they do not eat.

Signs and tests:

An indirect bilirubin blood test shows changes that occur with Gilbert's disease.

A genetic problem is associated with Gilbert's disease, but genetic testing is not needed.

Treatment:

No treatment is necessary for Gilbert's disease.

Expectations (prognosis):

Jaundice may come and go throughout your life, especially during illnesses such as colds. It does not cause health problems, but it can confuse the results of tests for jaundice.

Complications:

There are no known complications.

Calling your health care provider:

Call your health care provider if you have jaundice or persistent abdominal pain.

Prevention:

There is no proven prevention.