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Hyperparathyroidism - secondary
Secondary hyperparathyroidism is when the parathyroid glands in your neck produce too much parathyroid hormone (PTH) because your calcium levels are too low.
The parathyroid glands help control calcium use and removal by the body. They do this by producing parathyroid hormone, or PTH. PTH helps control calcium, phosphorus, and vitamin D levels within the blood and bone.
When calcium levels are too low, the body responds by increasing production of parathyroid hormone. This increase in parathyroid hormone causes more calcium to be taken from the bone and more calcium to be reabsorbed by the intestines and kidney.
Medical conditions that cause low blood calcium levels or interfere with the body's ability to break down and remove phosphate can lead to secondary hyperparathyroidism. Too much phosphate causes changes in calcium levels.
Kidney failure is a common cause of secondary hyperparathyroidism. Kidney failure can interfere with the body's ability to remove phosphate.
Other causes of secondary hyperparathyroidism may include:
Wysolmerski JJ, Insogna KL. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008:chap. 266.
Bringhurst FR, Demay MB, Kronenberg HM. Disorders of mineral metabolism. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008:chap. 27.
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