Definition of Alcoholic ketoacidosis:

Alcoholic ketoacidosis is the buildup of ketones in the blood. Ketones are a type of acid that form when the body breaks down fat for energy.

The condition is an acute form of metabolic acidosis.

Causes, incidence, and risk factors:

Alcoholic ketoacidosis is caused by excessive alcohol use. It is most often seen in a malnourished person who drinks large amounts of alcohol every day.

Symptoms:

• Abdominal pain
• Agitation
• Changed level of alertness, which may lead to coma
• Confusion
• Fatigue
• Slow, sluggish, lethargic movement
• Irregular deep, rapid breathing (Kussmaul's sign)
• Loss of appetite
• Nausea and vomiting
• Symptoms of dehydration, such as dizziness, light-headedness, and thirst

Signs and tests:

• Arterial blood gases (measure the acid/base balance and oxygen level in blood)
• Blood alcohol level
• Blood chemistries, such as CHEM-20
• Toxicology (poison) screening
• Urine ketones

Treatment:

Treatment may involve fluids (salt and sugar solution) given through a vein. You may need to have your blood taken often. You may get vitamin supplements to treat nutritional deficiencies caused by excess alcohol use.

People with this condition are admitted to the hospital, often to the intensive care unit (ICU).

Expectations (prognosis):

Prompt medical attention improves the overall outlook. How severe the alcoholism is, and the presence of liver disease or other complications also affect the outlook.

Complications:

This can be a life-threatening disorder. Complications can include:

• Gastrointestinal bleeding
• Pancreatitis (inflammation of the pancreas)
• Pneumonia

Calling your health care provider:

If you or someone else has symptoms of alcoholic ketoacidosis, seek emergency medical help.

Prevention:

Limiting the amount of alcohol you drink may help prevent this condition.