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Home > Medical Reference > Encyclopedia (English)

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Glucagonoma - Overview

Definition of Glucagonoma:

Glucagonoma is a very rare tumor of the islet cells of the pancreas, which release the hormones insulin and glucagon.

Causes, incidence, and risk factors:

Glucagonoma is usually cancerous (malignant). The cancer tends to spread and get worse.

This cancer affects the islet cells of the pancreas. As a result, they produce too much of the hormone glucagon.

The cause is unknown, but genetic factors play a role in some cases. A family history of multiple endocrine neoplasia type I (MEN I) is a risk factor.

  • Reviewed last on: 9/4/2008
  • Sean O. Stitham, MD, private practice in Internal Medicine, Seattle, Washington; and James R. Mason, MD, Oncologist, Director, Blood and Marrow Transplantation Program and Stem Cell Processing Lab, Scripps Clinic, Torrey Pines, California. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Simon P, Spilcke-Liss E, Wallaschofski H. Endocrine tumors of the pancreas. Endocrinol Metabl Clin North Am. 2006;35:431-437.

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