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Milk-alkali syndrome is caused by excessive consumption of milk (which is high in calcium) and certain antacids, especially calcium carbonate or sodium bicarbonate (baking soda), over a long period of time.
Calcium deposits in the kidneys and in other tissues can occur in milk-alkali syndrome. Consumption of excessive amounts of vitamin D, which is usually added to milk bought at the supermarket, can worsen this condition.
In the past, milk-alkali syndrome was often a side effect of treating peptic ulcer disease with antacids containing calcium. It is rarely seen today, because newer, better medications are available for treating ulcers. A more common scenario today is when someone takes too much calcium carbonate in an attempt to prevent osteoporosis. This syndrome has been reported in persons who take as little as 2 grams of calcium per day.
Wysolmerski JJ, Insogna KL. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 266.
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