Hypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones.
The pituitary gland is a small structure that is located just below the brain. It is attached by a stalk to the hypothalamus, the area of the brain that controls its function.
The hormones released by the pituitary gland (and their functions) are:
In hypopituitarism, there is a lack of one or more pituitary hormones. Lack of the hormone leads to loss of function in the gland or organ that it controls. For example, no TSH leads to loss of function in the thyroid gland.
Hypopituitarism may be caused by:
Occasionally, hypopituitarism is due to uncommon immune system or metabolic diseases, such as:
Hypopituitarism is also a rare complication after pregnancy, a condition called Sheehan's syndrome.
Melmed S, Kleinberg D. Anterior pituitary. In: Kronenberg H, Melmed S, Polonsky K, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 8.
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