Symptoms:

• Intolerance to cold
• Weight gain - mild
• Fatigue
• Constipation
• Enlarged neck or presence of goiter
• Small or atrophic thyroid gland (late in the disease)
• Dry skin
• Hair loss
• Heavy and irregular menses
• Difficulty concentrating or thinking

Additional symptoms that may be associated with this disease:

• Weight gain (unintentional)
• Joint stiffness
• Facial swelling

Note: There may be no symptoms.

Signs and tests:

Laboratory tests to determine thyroid function include:

• Free T4 test (low)
• Serum TSH (high)
• T3 (low or normal)
• Thyroid autoantibodies are frequently present:
  • antithyroid peroxidase antibody
  • antithyroglobulin antibody

This disease may also alter the results of the following tests:

• Radioactive iodine uptake
• Complete blood count
• Total cholesterol
• Serum sodium
• Serum prolactin