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High blood cholesterol levels - Overview

Alternative Names

Lipid disorders; Hyperlipoproteinemia; Hyperlipidemia; Dyslipidemia; Hypercholesterolemia

Definition of High blood cholesterol levels:

Cholesterol is a fat (also called a lipid) that your body needs to work properly. Cholesterol levels that are too high can increase your chance of getting heart disease, stroke, and other problems.

The medical term for high blood cholesterol is lipid disorder, or hyperlipidemia.

Causes, incidence, and risk factors:

There are many types of cholesterol. The ones talked about most are:

  • Total cholesterol - all the cholesterols combined
  • High density lipoprotein (HDL) cholesterol - often called "good" cholesterol
  • Low density lipoprotein (LDL) cholesterol - often called "bad" cholesterol

For most people, abnormal cholesterol levels are the result of an unhealthy lifestyle -- most commonly, eating a diet that is high in fat. Other lifestyle factors are:

  • Being overweight
  • Heavy alcohol use
  • Lack of exercise and leading an inactive lifestyle

Diabetes and an underactive thyroid gland may lead to high cholesterol levels. Other illnesses that may raise cholesterol levels include polycystic ovary syndrome and kidney disease.

Higher levels of female hormones increase or change cholesterol levels. This may include women who take birth control pills or estrogen, or who are pregnant,

Medicines such as certain diuretics (water pills), beta-blockers, and some medicines used to treat depression may also raise cholesterol levels.

Several disorders that are passed down through families lead to abnormal cholesterol and triglyceride levels. They include:

Smoking does not cause higher cholesterol levels, but it can reduce your HDL ("good") cholesterol.

  • Reviewed last on: 5/20/2011
  • David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

American Heart Association. Drug therapy for cholesterol. 2011 Jan 20. Accessed February 21, 2011.

Daniels SR, Greer FR; Committee on Nutrition. Lipid screening and cardiovascular health in childhood. Pediatrics. 2008;122198-208.

Gennest J, Libby P. Lipoprotein disorders and cardiovascular disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 47.

U.S. Preventive Services Task Force. Screening for lipid disorders in adults: U.S. Preventive Services Task Force recommendation statement. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); 2008 Jun. Accessed May 19, 2011.

U.S. Preventive Services Task Force. Screening for lipid disorders in children. U.S. Preventive Services Task Force recommendation statement. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); 2007 Jul. Accessed May 19, 2011.

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