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Interstitial cystitis (IC)

• Overview
• Symptoms
• Treatment

Alternative Names:

Cystitis - interstitial; IC

Treatment:

There is no cure for IC, nor are there any standard or consistently effective treatments. Results vary from individual to individual. As long as the cause is unknown, treatment is based on trial and error until relief is found.

Elmiron is the only medication taken by mouth that is specifically approved for the treatment of IC. This medicine coats the bladder like Pepto-Bismol coats the stomach.

Other medicines may include:

• Tricyclic antidepressants such as Elavil (amitriptyline) may relieve pain and urinary frequency
• Vistaril (hydroxyzine pamoate), an antihistamine that causes sedation helps reduce urinary frequency
• Opioid painkillers for severe pain

Other therapies include:

• Instilled medications - medicines are placed directly into the bladder. Medicines that are given this way include dimethyl sulfoxide (DMS), heparin, Clorpactin, lidocaine, doxorubicin, or bacillus Calmette-Guerin (BCG) vaccine.
• Surgery, ranging from cystoscopic manipulation to bladder removal (cystectomy)
• Bladder hydrodistention (filling bladder with fluid)
• Bladder training (using relaxation techniques to train the bladder to go only at specific times)
• Physical therapy and biofeedback (may help relieve pelvic floor muscle spasms)

Diet modification

Some patients find that changes in their diet can help control symptoms. The idea is to avoid foods and beverages that can cause bladder irritation. Below are some of the foods that the Interstitial Cystitis Association says may cause bladder irritation.

• Aged cheeses
• Sour Cream
• Yogurt
• Chocolate
• Onions
• Tofu
• Soy
• Fava and lima beans
• Tomatoes
• Most fruits except blueberries, honeydew melon, and pears
• Rye bread
• Sourdough bread
• Meats that are cured, processed, smoked, canned, aged, or that contain nitrites
• Nuts except almonds, cashews, and pine nuts
• Alcohol
• Citrus juices
• Coffee
• Tea
• Cranberry juice (Note: Although cranberry juice is often recommended for urinary tract infections, it can make IC symptoms worse)
• Seasonings that contain MSG
• Artificial sweeteners

Experts suggest that you do not stop eating all these foods at one time. Instead, try eliminating one at a time to see if that helps relieve symptoms.

Support Groups:

For additional information and support, see interstitial cystitis support groups .

Expectations (prognosis):

Treatment results vary. Some people respond well to simple treatments and dietary changes. Others may require extensive treatments or surgery.

Complications:

• Chronic (long-term) pain that may cause a change in lifestyle
• Emotional trauma
• High costs associated with frequent medical visits
• Chronic depression
• Side effects of treatments (depending on the treatment)

Calling your health care provider:

Call your health care provider if you have symptoms suggestive of interstitial cystitis. Be sure to mention that you suspect this disorder. It is not well-recognized nor is it easily diagnosed.

References:

Nickel JC. Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin North Am . 2004; 88(2): 467-81, xii.

Mattox TF. Interstitial cystitis in adolescents and children: a review.  J Pediatr Adolesc Gynecol . 2004; 17(1): 7-11.

Metts JF. Interstitial Cystitis: Urgency and Frequency Syndrome. Am Fam Physician . 2001 Oct 1;64(7):1199-206.

Walsh PC. Campbell's Urology . 8th ed. St. Louis, Mo: WB Saunders; 2002:631-660. 

• Review Date: 5/3/2006
• Reviewed By: Neil D. Sherman, MD, Urologist, Essex County, NJ. Review provided by VeriMed Healthcare Network.

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