Kimmelstiel-Wilson disease; Diabetic glomerulosclerosis; Nephropathy - diabetic
Diabetic nephropathy is kidney disease or damage that occurs in people with diabetes.
Each kidney is made of hundreds of thousands of small units called nephrons. These structures filter your blood and help remove wastes from your body.
In people with diabetes, the nephrons thicken and slowly become scarred over time. The kidneys begin to leak and protein (albumin) passes into the urine.
The exact cause is unknown. Poor control of blood sugar is thought to lead to kidney damage. If you also have high blood pressure, kidney damage is even more likely.
In some cases, your family history may also play a role. Not everyone with diabetes develops this kidney problem.
People with diabetes who smoke, and those with type 1 diabetes that started before age 20 have a higher risk for kidney problems.
People of African-American, Hispanic, and American Indian origin are also more likely to have kidney damage.
American Diabetes Association. Standards of medical care in diabetes--2011. Diabetes Care. 2011 Jan;34 Suppl 1:S11-61.
Inzucchi SE, Sherwin RS. Diabetes Mellitus. In: Goldman L, Ausiello D, eds. Cecil Textbook of Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 248.
American Diabetes Association (2004). Nephropathy in diabetes. Clinical Practice Recommendations 2004. Diabetes Care. 27(Suppl 1): S79ï¿½S83.
Parving H, Mauer M, Ritz E. Diabetic Nephropathy. In: Brenner BM. Brenner and Rector's The Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 36.
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