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Diabetes insipidus - nephrogenic - Symptom

Alternative Names

Nephrogenic diabetes insipidus; Acquired nephrogenic diabetes insipidus

Symptoms:

You may have intense or uncontrollable thirst, and crave ice water. You will produce large amounts of urine, usually more than 3 - 15 liters per day.

If you do not drink enough fluids, dehydration can result. Symptoms may include:

Dry mucus membranes
Dry skin
Sunken appearance to eyes
Sunken fontanelles (soft spot) in infants

Other symptoms that can occur due to inadequate fluids include:

Fatigue, lethargy
Headache
Irritability
Low body temperature
Muscle pains
Rapid heart rate
Weight loss

Signs and tests:

A physical exam may reveal:

Low blood pressure
Rapid pulse
Shock
Signs of dehydration

Testing may reveal:

High serum osmolality
High urine output, regardless of how many fluids you drink
Kidneys don't concentrate urine when the person is given ADH
Low urine osmolality
Normal or high ADH levels

Other tests that may be done include:

Male urinary system

Reviewed last on: 4/14/2008
Parul Patel, MD, Private Practice specializing in Nephrology and Kidney and Pancreas Transplantation, Affiliated with California Pacific Medical Center, Department of Transplantation, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Verbalis JG. Anatomy and hormone synthesis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 243.

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