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Von Willebrand disease

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Definition:

Von Willebrand disease is the most common hereditary bleeding disorder .

Causes, incidence, and risk factors:

Von Willebrand disease is caused by a deficiency of von Willebrand factor. Von Willebrand factor helps platelets to clump together and stick to the blood vessel wall, which is necessary for normal blood clotting.

Von Willebrand disease affects both men and women. Most cases are mild. Bleeding may occur after surgery or when you have a tooth pulled. Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) can make this condition worse. Bleeding may decrease during pregnancy.

A family history of a bleeding disorder is the primary risk factor. In women with heavy or prolonged menstrual bleeding, von Willebrand is more common in Caucasian women than African American women.

References:

Kumar V, Abbas AK, Fausto N. Robbins and Cotran Pathologic Basis of Disease . 7th ed. St. Louis, Mo: WB Saunders; 2005:654-655.

Noble J. Textbook of Primary Care Medicine . 3rd ed. St. Louis, Mo: Mosby; 2001:1047.

Marx J. Rosen’s Emergency Medicine: Concepts and Clinical Practice . 5th ed. St. Louis, Mo: Mosby; 2002:1693.

• Review Date: 2/7/2006
• Reviewed By: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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