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Factor XII (Hageman factor) deficiency

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Definition:

Factor XII deficiency is an inherited disorder with no symptoms. Factor XII is a protein involved in blood clotting. A deficiency of this factor does not cause abnormal bleeding in the affected person, but the blood takes longer than normal to clot in a test tube.

Causes, incidence, and risk factors:

Factor XII deficiency is a rare hereditary disorder. It is usually found when clotting tests are done for routine screening. It is not associated with abnormal bleeding.

References:

McPherson RA and Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods . 21st ed. Philadelphia, Pa.: WB Saunders; 2006.

Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philladelphia, Pa: Churchill Livingston; 2005:2089-90.

• Review Date: 2/26/2007
• Reviewed By: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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