Definition of Factor VII deficiency:

Factor VII deficiency is an inherited disorder in which a lack (deficiency) of plasma protein factor VII leads to abnormal bleeding.

Causes, incidence, and risk factors:

This disorder occurs when the body does not have enough factor VII, an important blood clotting protein.

When you bleed, the body launches a series of reactions that help the blood clot. The process involves special proteins called coagulation factors. Factor VII is one of many coagulation factors. The final product of these reactions is the blood clot.

When certain coagulation factors are missing, your blood may not clot normally and you can bleed abnormally. Bleeding can vary from mild to severe in the same person over time. Bleeding may begin during infancy or childhood.

Most often a deficiency of factor VII is caused by:

• Severe liver disease
• Use of drugs that prevent clotting (anticoagulants such as warfarin or coumadin)
• Lack of vitamin K due to long-term use of antibiotics, bile duct obstruction, or poor absorption of vitamin K from the intestines

Some babies are born with vitamin K deficiency. It is very rare to be born with factor VII deficiency that is due to the body's inability to make working factor VII.