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Paroxysmal cold hemoglobinuria (PCH) - Symptom
Alternative Names
PCH
Symptoms:
- Chills
- Fever
- Back pain
- Leg pain
- Abdominal pain
- Headache
- General discomfort, uneasiness, or ill feeling (malaise)
- Blood in the urine (red urine)
Signs and tests:
- Donath-Landsteiner test is positive
- Serum hemoglobin is higher during attacks
- Urine hemoglobin is higher
- CBC shows anemia
- Coombs test is negative
- Bilirubin is high
- LDH is high
- Reviewed last on: 3/13/2007
- Mark Levin, MD, Hematologist and Oncologist, Newark, NJ. Review provided by VeriMed Healthcare Network.
References
Ferri FF. Ferri's Clinical Advisor 2007. 1st ed. Philadelphia, Pa: Mosby; 2006.
Hoffman R, Benz E, Shattil S, Furie B, Cohen H. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, Pa: Churchill Livingstone; 2004.
Roddr EG, Hillmen P, Schreiber AD. Immune-mediated hemolytic anemia. Hematology Am Soc Hematol Educ Program. January 2004;48-62.
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