Symptoms:

• Fever
• Sore throat
• Enlarged lymph nodes, especially in the neck
• Malaise (vague ill feeling)
• Frequent tiredness or fatigue
• Loss of appetite
• Muscular aches or stiffness

• Jaundice (yellow cast to skin)
• Headache
• Neck stiffness
• Sensitivity to light
• Cough
• Shortness of breath
• Chest pain
• Rapid heart rate
• Irregular heart rate
• Hives

Signs and tests:

Your health care provider will perform a physical exam and feel your belly area. The liver and spleen may be tender when they are gently pressed (palpated). There may be a skin rash.

Special lab tests will be done to check for substances in your blood that are produced by CMV. This includes a CMV ELISA antibody test and CMV serum PCR test.

A monospot test should be negative in CMV mononucleosis.

Blood tests show a low number of platelets and a high number of certain white blood cells.

A chemistry panel may show abnormal liver enzymes.