Symptoms:

• Fatigue
• Fever and chills
• Itching
• Loss of appetite
• Night sweats
• Painless swelling of the lymph nodes in the neck, armpits, or groin (swollen glands)
• Weight loss

Other symptoms that may occur with this disease:

• Clubbing of the fingers or toes
• Excessive sweating
• Flank pain
• Hair loss
• Neck pain
• Pain in the affected areas after drinking alcohol
• Skin blushing or flushing
• Splenomegaly

Signs and tests:

The disease may be diagnosed after:

• Biopsy of suspected tissue
• Bone marrow biopsy
• Lymph node biopsy
• Detection of Reed-Sternberg (Hodgkin's lymphoma) cells by biopsy from any site

A staging evaluation (tumor staging) may be done to determine how far the disease has spread. The following procedures may be done:

• Blood chemistry tests
• Bone marrow biopsy
• CT scans of the chest, abdomen, and pelvis
• PET scan
• Physical examination

In some cases, abdominal surgery to take a piece of the liver and remove the spleen may be needed. However, because the other tests are now so good at detecting the spread of Hodgkin's lymphoma, this surgery is usually unnecessary.

Hodgkin's lymphoma may change the results of the following tests:

• Angiotensin converting enzyme (ACE) levels
• Blood differential
• Bone marrow aspiration
• Cryoglobulins
• Ferritin
• Gallium scan
• Lymphocyte count