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Treatment decisions depend on the extent and location of the lesions, as well as the person's symptoms and degree of immunosuppression. Antiviral therapy against the AIDS virus can shrink the lesions.
Radiation therapy or cryotherapy can be used for lesions in certain areas. Combination chemotherapy may also be used. However, lesions may return after treatment.
Treatment and remission of Kaposi's sarcoma does not improve the chances of survival from AIDS itself. The outlook depends on the immune status and HIV viral load of the patient.
Kaposi's sarcoma can involve the lungs and cause significant symptoms, including cough and shortness of breath. This diagnosis is made by a CT scan of the chest and a bronchoscopy. The tumors can return even after apparently successful treatment. Kaposi's sarcoma can be fatal for a person with AIDS.
An aggressive form of African Kaposi's sarcoma can spread quickly to the bones. Another form found in African children does not affect the skin. Instead, it spreads through the lymph nodes and vital organs, and can quickly become fatal.