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Progressive multifocal leukoencephalopathy

Definition:

Progressive multifocal leukoencephalopathy (PML) is a rare inflammatory disorder that causes damage to the material ( myelin ) that covers nerves. The nerve damage related to PML occurs within the white matter of the brain .

Alternative Names:

PML

Causes, incidence, and risk factors:

PML is caused by the JC virus (JCV). This virus is found in a lot of people, but usually does not cause symptoms. However, it triggers PML in people who have poor immune function (immunocompromised).

The disease occurs in 4% of adults with AIDS.

References:

Mandell GL, Bennett JE, Dolin R. Principles and Practice of Infectious Diseases . 5th ed. London: Churchill Livingstone; 2000:1856-1861.

Cohen J, Powderly WG. Infectious Diseases . 2nd ed. New York, NY: Elsevier; 2004:2046.

Gray and white matter of the brain

Leukoencephalopathy

Review Date: 4/28/2006
Reviewed By: Daniel Kantor, M.D., Director of the Comprehensive MS Center, Neuroscience Institute, University of Florida Health Science Center, Jacksonville, FL. Review provided by VeriMed Healthcare Network.

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