Meningitis - syphilitic
The goals of treatment are to cure the infection and stop the disorder from getting worse. Treating the infection helps prevent new nerve damage and may reduce symptoms, but it does not reverse existing damage.
Penicillin or other antibiotics (such as tetracycline or erythromycin) are given to treat the infection. Treatment may be long-term to ensure that the infection is completely cleared. Symptoms may improve dramatically after treatment. A follow-up examination of the cerebrospinal fluid is needed to evaluate whether the antibiotic therapy worked.
Neurologic damage needs to be treated. You may need to have emergency treatment for seizures. Anticonvulsants such as phenytoin are used to control seizures.
Some people may need help eating, dressing, and caring for themselves. Confusion and other mental changes may either improve or continue long-term after antibiotic treatment.
Some people with the condition have worsening disability. Early death is common. Death can be caused directly by the neurologic damage or by the cardiovascular damage that also occurs with late syphilis infections.
People with late syphilis infections are at greater risk for other infections and diseases. A seizure disorder can develop after infection.
Go to the emergency room or call the local emergency number (such as 911) if you have seizures.
Call your health care provider if you have a severe headache with fever or other symptoms, especially if you have a history of syphilis infection.
Centers for Disease Control and Prevention (CDC). Recommendations and Reports: Sexually Transmitted Diseases. MMWR Morb Mortal Wkly Rep. 2006;55(RR-11).
U.S. Preventive Services Task Force. Screening for syphilis infection in pregnancy: U.S. Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med. 2009;150:705-709.
U.S. Preventive Services Task Force. Screening for syphilis infection. Topic Page. July 2004. Agency for Healthcare Research and Quality, Rockville, MD. Acccessed 6/28/2010.
Hook EW III. Syphilis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 340.
Tremont EC. Treponema pallidum (Syphilis). In: Mandell GL, Bennett JE, Dolin R, eds. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2009: chap 238.
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