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Mononeuritis multiplex - Overview

Alternative Names

Mononeuropathy multiplex; Multifocal neuropathy

Definition of Mononeuritis multiplex:

Mononeuritis multiplex is a brain/nervous system (neurological) disorder that involves damage to at least two separate nerve areas.

Causes, incidence, and risk factors:

Mononeuritis multiplex is a form of damage to nerves outside the brain and spinal cord (peripheral neuropathy). It is a group of symptoms, not a disease. A part of the nerve cell called the axon is destroyed, which interferes with nerve signaling.

The cause of mononeuritis multiplex affects nerves in many areas. As the disorder gets worse, the damage may become more widespread and affect more nerves. Common causes include:

  • A lack of oxygen from decreased blood flow
  • Swelling and irritation (inflammation) of blood vessels

No cause is found in about a third of cases.

Common causes of mononeuritis multiplex include:

Connective tissue disease is the most common cause of mononeuritis multiplex in children.

Less common causes include:

  • Reviewed last on: 9/25/2008
  • Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
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