Histamine headache; Headache - histamine; Migrainous neuralgia; Headache - cluster
A cluster headache is one-sided head pain that may involve tearing of the eyes and a stuffy nose. Attacks occur regularly for 1 week to 1 year, separated by long pain-free periods that last at least 1 month, possibly longer.
Cluster headaches are a fairly common form of chronic, repeated headaches. They are more common in men than women. The headaches can occur at any age but are most common in adolescence and middle age. They tend to run in families.
Scientists do not know exactly what causes cluster headaches, but they appear to be related to the body's sudden release of histamine or serotonin.
The following may trigger cluster attacks:
A cluster headache begins as a severe, sudden headache. The headache most commonly strikes 2 to 3 hours after falling asleep, usually during the dreaming (rapid eye movement, or REM) phase. However, the headache may occur while you are awake. The headache tends to occur at the same time of day.
The pain occurs on one side of the head. It may be described as:
The pain may occur in, behind, and around one eye. It may:
The strongest pain may last 30 minutes to 2 hours.
The eye and nose on the same side of the head pain may also be affected. Symptoms can include:
Cluster headaches may occur daily for months, alternating with periods without headaches (episodic), or they can recur for a year or more without stopping (chronic).
Your health care provider can diagnosis this type of headache by performing a physical exam and asking questions about your symptoms and medical history.
If a physical exam is done during an attack, the exam will usually reveal Horner syndrome (one-sided eyelid drooping or a small pupil). These symptoms will not be present at other times. No other neurological changes will be seen.
Tests, such as an MRI of the head, may be needed to rule out other causes for the headaches.
Treatment does not cure cluster headaches. The goal of treatment is to relieve symptoms. The headaches may go away on their own, or you may need treatment to prevent them.
Smoking, alcohol use, specific foods, and other factors that seem to trigger cluster headaches should be avoided. A headache diary can help you identify your headache triggers. When you get a headache, write down the day and time the pain began. The diary should include notes about what you ate and drank in the last 24 hours, how much you slept and when, and what was going on in your life immediately before the pain started. For example, were you under any unusual stress? Also include information about how long the headache lasted, and what made it stop.
Treatment for cluster headaches involves:
Your doctor may recommend the following treatments for when the headaches occurs:
A combination of medicines may be needed to control headache symptoms. Because each person responds differently to medicine, your doctor may have you try several medications before deciding which works best for you.
Painkillers do not usually relieve the pain from cluster headaches. Generally, they take too long to work.
The following medications may also be used to treat or prevent headache symptoms:
In rare cases, surgery on certain nerve cells near the brain may be recommended if medications do not work.
Cluster headaches are not life-threatening and usually cause no permanent structural changes. However, they are chronic and often painful enough to interfere with work or lifestyle. Occasionally, the pain may be so severe that some people may consider self harm.
Side effects of medications or surgery may be severe.
Call for an appointment with your health care provider if cluster headaches do not respond to treatment, if headaches disturb sleep, if they happen whenever you are active, or are accompanied by other symptoms.
Emergency symptoms include drowsiness, vision changes, changes in movement or sensation, seizures, changes in alertness, and nausea or vomiting.
If prone to cluster headache, stop smoking. Alcohol use and any foods that are associated with cluster headache may need to be avoided. Medications may prevent cluster headaches in some cases.
Silberstein SD, Young WB. Headache and facial pain. In: Goetz CG. Textbook of Clinical Neurology. 3rd ed. St. Louis, Mo: WB Saunders; 2007:chap 53.
Bartsch T, Paemeleire K, Goadsby PJ. Neurostimulation approaches to primary headache disorders. Curr Opin Neurol. 2009;22(3):262-268.
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