Symptoms:

• Blurred vision (sometimes)
• Changes in gait (walking)
• Hallucinations
• Lack of coordination (for example, stumbling and falling)
• Muscle twitching
• Muscle stiffness
• Myoclonic jerks or seizures
• Nervous, jumpy feelings
• Personality changes
• Profound confusion, disorientation
• Rapidly developingdelirium or dementia
• Sleepiness
• Speech impairment

Additional symptoms that may be associated with this disease:

• Memory loss
• Anxiety, stress, and tension

Once symptoms appear, the disorder progresses rapidly and may be confused with other types of dementia -- like Alzheimer's disease. Both forms of CJD, however, are distinguished by extremely rapid progression from onset of symptoms to disability and death.

Signs and tests:

A neurological and motor system examination shows muscle twitching and spasm. There is a strong startle response. Muscle tone may be increased, or there may be weakness and muscle wasting (loss of muscle tissue). There may be abnormal reflexes or an increase in the response of normal reflexes.

There is loss of coordination related to visual-spatial perception changes and changes in the cerebellum, the area of the brain that controls coordination (cerebellar ataxia). An eye examination shows areas of blindness that the person may not realize are present.

Tests used to diagnose this condition may include:

• EEG
• Spinal tap

Ultimately, the disease can only be confirmed by brain biopsy or autopsy.