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Erythema multiforme - Symptom

Alternative Names

Lyell's syndrome; Stevens-Johnson syndrome; Erythema multiforme minor; Erythema multiforme major

Symptoms:

  • Fever
  • General ill feeling
  • Itching of the skin
  • Joint aches
  • Multiple skin lesions:
    • Start quickly and may return
    • May spread
    • May appear as a nodule, papule, or macule and may look like hives
    • Central sore surrounded by pale red rings, also called a "target", "iris", or "bulls-eye"
    • May have vesicles and blisters of various sizes (bullae)
    • Located on the upper body, legs, arms, palms, hands, or feet
    • May involve the face or lips
    • Usually even on both sides (symmetrical)

Other symptoms that may occur with this disease:

Signs and tests:

The diagnosis is based mainly on the appearance of the skin lesion, especially if there is a history of risk factors or related diseases.

Tests may include:

  • Reviewed last on: 10/10/2010
  • Linda J. Vorvick, MD, Medical Director, MEDEX Northwest Division of Physician Assistant Studies, University of Washington School of Medicine. Also reviewed by Kevin Berman, MD, PhD, Atlanta Center for Dermatologic Disease, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2009:pp 710-714.

Weber DJ, Cohen MS, Morrell DS, Rutala WA. The acutely ill patient with fever and rash. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Disease. Philadelphia, Pa: Elsevier Churchill Livingstone; 2009:chap 52.

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