The underlying infection, drug, or disease should be identified and treated. Nonsteroidal anti-inflammatory medications (NSAIDs) may reduce symptoms. An oral potassium iodide (SSKI) solution may produce prompt resolution of the nodules.
Corticosteroids or salicylate medications may be needed to reduce acute inflammation. Analgesics and limitation of activity may be needed to control varying amounts of pain.
Topical therapy is not generally needed, although hot or cold compresses may reduce discomfort.
Erythema nodosum is uncomfortable, but it is usually not dangerous. Symptoms typically disappear within about 6 weeks, but may recur.
Call for an appointment with your health care provider if you develop symptoms of erythema nodosum.
Schwartz RA, Nervi SJ. Erythema nodosum: a sign of systemic disease. Am Fam Physician. 2007;75(5):695-700.
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