Definition of Pemphigus vulgaris:

Pemphigus vulgaris is an autoimmune disorder that involves blistering of the skin and mucous membrane.

Causes, incidence, and risk factors:

Pemphigus is an autoimmune disorder. The immune system produces antibodies against specific proteins in the skin and mucous membrane. These antibodies create a reaction that cause skin cells to separate. The exact cause is unknown.

Sometimes pemphigus is caused by certain medications, although this is rare. Medications that may cause this condition include:

• Blood pressure medications called ACE inhibitors
• Chelating agents such as penicillamine, which remove certain materials from the blood

Pemphigus is uncommon. It occurs almost exclusively in middle-aged or older people.