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Barbiturate intoxication and overdose - Overview

Alternative Names

Intoxication - barbiturates

Definition of Barbiturate intoxication and overdose:

Barbiturates are a type of depressant drug that cause relaxation and sleepiness. In relatively low doses, barbiturates and alcohol have very similar clinical syndromes of intoxication.

However, excessive and prolonged dosages of barbiturate drugs, such as phenobarbital, may produce the following chronic symptoms: memory loss, irritability, changes in alertness, and decreased interpersonal functioning. Barbiturates may also cause an acute overdose syndrome, which is life-threatening.

Causes, incidence, and risk factors:

Barbiturate abuse is still a major addiction problem in the population, although it has been partly replaced by addiction to other depressant drugs more commonly prescribed, such as benzodiazepines.

Though most people who take these medications for seizure disorders or pain syndromes do not abuse them, many abusers start by abusing medication prescribed for them or for other family members.

Reviewed last on: 1/14/2010
Jacob L. Heller, MD, MHA, Emergency Medicine, Virginia Mason Medical Center, Seattle, Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Schears RM. Barbiturates. In: Tintinalli JE, Kelen GD, Stapczynski JS, Ma OJ, Cline DM, eds. Emergency Medicine: A Comprehensive Study Guide. 6th ed. New York, NY: McGraw-Hill; 2004:chap 163.

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