Retinoblastoma - Overview
Tumor - retina; Cancer - retina
Definition of Retinoblastoma:
Retinoblastoma is a rare, cancerous tumor of a part of the eye called the retina.
Causes, incidence, and risk factors:
Retinoblastoma is caused by a mutation in a gene controlling cell division, causing cells to grow out of control and become cancerous.
In a little over half of the cases, this mutation develops in a child whose family has never had eye cancer.
Other times the mutation is present in several family members. If the mutation runs in the family, there is a 50% chance that an affected person's children will also have the mutation. They will therefore have a high risk of developing retinoblastoma themselves.
The cancer generally affects children under the age of 6. It is most commonly diagnosed in children aged 1 - 2 years.
- Reviewed last on: 3/21/2010
- David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc., and Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital.
Dome JS, Rodriguez-Galindo C, Spunt SL, Santana VM. Pediatric sold tumors. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKenna WG, eds. Abeloff’s Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 99.
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