Definition of Gallbladder disease:

Gall bladder disease includes inflammation, infection, stones, or obstruction of the gallbladder.

Causes, incidence, and risk factors:

The gallbladder is a sac located under the liver. It stores and concentrates bile produced in the liver. Bile aids in the digestion of fats, and is released from the gallbladder into the upper small intestine (duodenum) in response to food (especially fats). Conditions that slow or obstruct the flow of bile out of the gallbladder result in gallbladder disease.

Types of gallbladder disease include:

• Cholecystitis (inflammation of the gallbladder)
• Cholelithiasis (gallstones)

Symptoms:

• Abdominal fullness or gas
• Abdominal pain that is:
  • Severe
  • Located on the right side (right upper quadrant) or in the upper middle of the abdomen (epigastric)
  • Decreased over 12 to 18 hours in uncomplicated cases
  • Recurrent or similar to pain in past
  • Occurring after meals
  • Worse during deep intake of breath
  • Radiating to back or below the right shoulder blade
  • Worse after eating or drinking fatty foods or fluids
• Chest pain under the breastbone
• Chills and shaking
• Fever
• Heartburn
• Nausea and vomiting

Signs and tests:

The abdomen is tender to the touch.

Tests that detect gallstones or inflammation include:

• Abdominal CT scan
• Abdominal ultrasound
• Abdominal x-ray
• A CBC shows infection by an elevated white blood cell count

This disease may also alter the results of the following tests:

• Amylase
• Amylase, urine
• Chemistry panel (chem-20)
• Lipase

Treatment:

Treatment depends on the specific type of gallbladder disease.

Expectations (prognosis):

See the specific type of gallbladder disease.

Complications:

See the specific type of gallbladder disease.

Calling your health care provider:

Call your provider if you develop symptoms of gallbladder disease.

Prevention:

In most cases, prevention is not possible. Weight reduction, and reducing intake of fatty foods, may reduce symptoms in people with gallbladder disease. Use of the medicine ursodiol may shrink gallstones, but it is used only in special cases.