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Ovarian overproduction of androgens - Symptom

Symptoms:

Hyperadrogenism:

  • Acne
  • Amenorrhea (absence of menstrual periods)
  • Changes in female body contours
  • Decrease in breast size
  • Increase in body hair in a male pattern (hirsutism)
  • Oily skin

Virilization:

  • Clitoromegaly (enlargement of the clitoris)
  • Deepening of the voice
  • Increase in muscle mass
  • Temporal balding (thinning hair and hair loss)

Signs and tests:

  • 17-hydroxyprogesterone
  • ACTH test
  • CT scan
  • Glucose and insulin level tests
  • Pelvic ultrasound
  • Prolactin (if periods are infrequent or absent)
  • Testosterone
  • TSH (if there is balding)
  • Reviewed last on: 5/12/2008
  • Susan Storck, MD, FACOG, Clinical Teaching Faculty, Department of Obstetrics and Gynecology, University of Washington School of Medicine; Chief, Eastside Department of Obstetrics and Gynecology, Group Health Cooperative of Puget Sound, Redmond, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Lobo RA. Hyperandrogenism: Physiology, Etiology, Differential Diagnosis, Management. In: Katz V, Lobo RA, Lentz G, Gershenson D, eds. Comprehensive Gynecology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2007:chap 40.
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