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Gigantism is abnormally large growth due to an excess of growth hormone during childhood, before the bone growth plates have closed.
The most common cause of too much growth hormone release is a noncancerous (benign) tumor of the pituitary gland. Other causes include:
If excess growth hormone occurs after normal bone growth has stopped, the condition is known as acromegaly.
Gigantism is very rare.
Melmed S, Kleinberg D. Anterior pituitary. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR. Williams Textbook of Endocrinology. 11th ed. Philadelphia, PA: Saunders Elsevier; 2008:chap 8.
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