Get answers to your Parathyroid Disorders questions.
Parathyroid hyperplasia is the enlargement of all four parathyroid glands. The parathyroid glands are four glands in the neck that produce parathyroid hormone (PTH).
Parathyroid hyperplasia may occur sporadically (in persons without a family history of the disease) or as part of three inherited syndromes: multiple endocrine neoplasia I (MEN I), MEN IIA, and isolated familial hyperparathyroidism.
In the familial syndromes, a mutated gene is passed down in an autosomal dominant fashion. That means you only need to get the gene from one parent to develop the condition.
In MEN I, the problems in the parathyroids are associated with other tumors in the pituitary and the pancreas. In MEN IIA, the overactivity of the parathyroids is associated with tumors in the adrenal gland or thyroid. See the specific articles for more information on the causes of these syndromes.
Wysolmerski JJ, Insogna KL. The parathyroid glands, hypercalcemia, and hypocalcemia. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008:chap. 266.
Bringhurst FR, Demay MB, Kronenberg HM. Disorders of mineral metabolism. In: Kronenberg HM, Schlomo M, Polansky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 11th ed. St. Louis, Mo: WB Saunders; 2008:chap. 27.
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