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Neonatal hypothyroidism - Overview

Alternative Names

Cretinism; Congenital hypothyroidism; Hypothyroidism - infants

Definition of Neonatal hypothyroidism:

Neonatal hypothyroidism is decreased thyroid hormone production in a newborn. In very rare cases, no thyroid hormone is produced.

If the baby was born with the condition, it is called congenital hypothyroidism. If it develops soon after birth, it is referred to as hypothyroidism acquired in the newborn period.

Causes, incidence, and risk factors:

Hypothyroidism in the newborn may be caused by:

  • A missing or abnormally developed thyroid gland
  • Pituitary gland's failure to stimulate the thyroid
  • Defective or abnormal formation of thyroid hormones

Incomplete development of the thyroid is the most common defect and occurs in about 1 out of every 3,000 births. Girls are affected twice as often than boys.

  • Reviewed last on: 8/15/2007
  • Alan Greene, MD, FAAP, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital; Chief Medical Officer, A.D.A.M., Inc. Previously reviewed by Robert Hurd, MD, Professor of Endocrinology, Department of Biology, Xavier University, Cincinnati, OH, and physician in the Primary Care Clinic, Cincinnati Veterans Administration Medical Center, Cincinnati, Ohio. Review provided by VeriMed Healthcare Network. (7/17/2007)

References

Harris KB, Pass KA. Increase in congenital hypothyroidism in New York State and in the United States. Mol Genet Metab. 2007; 91(3):268-277.

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