McCune-Albright syndrome

Alternative Names:

Polyostotic fibrous dysplasia

Treatment:

There is not a specific treatment for McCune-Albright syndrome. Drugs that inhibit estrogen production, such as testolactone, have been tried with some success.

Adrenal abnormalities (such as Cushing's syndrome ) may be treated by surgery to remove the adrenal glands. Gigantism and pituitary adenoma will require treatment with hormone inhibitors or surgery.

Expectations (prognosis):

Life span is relatively normal.

Complications:

Repeated episodes of broken bones
Cosmetic problems resulting from bone abnormalities
Blindness
Deafness
Tumors
Premature puberty
Osteitis fibrosa cystica

Calling your health care provider:

Call your health care provider if your child develops evidence of premature puberty (before the expected age) or has other symptoms suggestive of McCune-Albright syndrome. Genetic counseling, and possibly genetic testing, may be recommended if the disease is diagnosed.

Anterior skeletal anatomy

Review Date: 8/11/2006
Reviewed By: Brian Kirmse, MD, Mount Sinai School of Medicine, Department of Human Genetics, New York, NY. Review provided by VeriMed Healthcare Network.

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