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Hallervorden-Spatz disease - Overview

Definition of Hallervorden-Spatz disease:

Hallervorden-Spatz disease is a movement disorder that is passed down through families (inherited).

Causes, incidence, and risk factors:

Hallervorden-Spatz usually begins in childhood.

Most cases of Hallervorden-Spatz are due to a defect in a gene that makes a protein called pantothenate kinase 2. Patients with this genetic defect have a buildup of iron in parts of the brain.

  • Reviewed last on: 9/22/2008
  • Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.

References

Jankovic J. Movement disorders. In: Goetz CG, ed. Textbook of Clinical Neurology. 3rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 34.

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