Dupuytren's contracture is a painless thickening and contracture of tissue beneath the skin on the palm of the hand and fingers.
The cause is unknown. Family history of Dupuytren's contracture makes you more likely to develop this condition. It does not seem to be caused by occupation or from trauma.
The condition becomes more common after the age of 40. Men are affected more often than women. Risk factors are alcoholism, diabetes, and smoking.
Stretanski MF. Dupuytren contracture. In: Frontera, WR, Silver JK, Rizzo TD Jr, eds. Essentials of Physical Medicine and Rehabilitation. 2nd ed. Philadelphia, Pa: Saunders Elsevier; 2008:chap 25.
Gilpin D, Coleman S, Hall S, Houston A, Karrasch J, Jones N. Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease. J Hand Surg Am. 2010 Dec;35(12):2027-38.e1. PubMed PMID: 21134613.
Hurst LC, Badalamente MA, Hentz VR, et al; CORD I Study Group. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Engl J Med. 2009 Sep 3;361(10):968-79. PubMed PMID: 19726771.
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