Chronic granulomatous disease - Symptom
CGD; Fatal granulomatosis of childhood; Chronic granulomatous disease of childhood; Progressive septic granulomatosis
- Bone infections
- Frequent and difficult-to-clear skin infections
- Chronic infection inside the nose
- Impetiginized eczema (eczema complicated by an infection)
- Perianal abscesses (abscesses around the anus)
- Joint infections
- Persistent diarrhea
- Occurs frequently
- Difficult to cure
- Swollen lymph nodes in the neck; those develop early in life, and stay swollen or occur frequently. The lymph nodes may form abscesses that require surgical drainage.
Signs and tests:
Physical examination may show an enlarged liver (hepatomegaly), enlarged spleen (splenomegaly), and swelling of multiple lymph nodes all over the body (generalized adenopathy). There may be signs of a bone infection (osteomyelitis ), sometimes affecting multiple bones.
A tissue biopsy may show granulomas (groups of abnormal phagocytes).
Other tests may include:
- Reviewed last on: 9/15/2010
- David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Instructor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Boxer LA. Disorders of phagocyte function. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th Ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 129.
Glogauer M. Disorders of phagocyte function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 175.
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