Glanzmann's disease is caused by the lack of a protein that is normally on the surface of platelets, which is needed for them to clump together (aggregate) normally.
The condition is congenital, which means it is present from birth. There are several genetic abnormalities that can cause the condition.
Bennett JS. Hereditary disorders of platelet function. In: Hoffman R, Benz EJ Jr., Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa: Churchill Livingstone Elsevier; 2008:chap 141.
McMillan R. Hemorrhagic disorders: Abnormalities of platelet and vascular function. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 179.
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